Nelfinavir (NFV) is an HIV-1 aspartyl protease inhibitor that has numerous effects on human cells, which impart attractive antitumor properties.NFV has also been shown to have in vitro inhibitory activity against human herpesviruses (HHVs).Given the apparent absence of an aspartyl protease encoded by HHVs, we investigated the mechanism of action of
Abstract Diabetic heart disease (DHD) is a serious complication in patients with diabetes.Despite numerous studies on the pathogenic Pycnogenol mechanisms and therapeutic targets of DHD, effective means of prevention and treatment are still lacking.The pathogenic mechanisms of DHD include cardiac inflammation, insulin resistance, myocardial fibrosi
We introduce a Schelling model in which people are modelled as agents following simple behavioural rules which dictate their tolerance to others, their corresponding preference for particular locations, and in turn their movement through a geographic or social space.Our innovation over previous work Wax Discs is to allow agents to adapt their toler